5. Nodular lymphocyte-predominant Hodgkin lymphoma 

The nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) subtype is very rare and occurs in just one out of 20 cases of the disease, mostly in young male patients.

• nodular lymphocyte-predominant Hodgkin lymphoma cells are “histolytic” and “lymphocytic” cells. In classic HL cases, they are Reed-Sternberg.
• NLPHL is indolent, which means, slow growing, That means that the odds of long-term survival are good.
• It is possible (3% risk) that NLPHL will transform into an non-Hodgkin lymphoma. 
• The treatments for this kind of subtype are generally different from standard first-line therapy for classic Hodgkin lymphoma

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