Epizyme and LYSA Open Clinical Trial of Combo Therapy for Diffuse Large B-Cell Lymphoma

Epizyme and LYSA Open Clinical Trial of Combo Therapy for Diffuse Large B-Cell Lymphoma

Epizyme, Inc., and the Lymphoma Study Association (LYSA) will jointly investigate the combination of tazemetostat and R-CHOP as a frontline treatment in patients with diffuse large B-cell lymphoma (DLBCL), the most common form of non-Hodgkin lymphoma (NHL).

Most NHLs originate in B-cells, a type of immune cell responsible for fighting infections through the production of antibodies. Lymphomas starting in either B-cells or T-cells significantly influence both prognosis and treatment.

The open-label trial will be conducted at multiple sites in France and will enroll elderly, high-risk patients with recently diagnosed DLBCL. In the Tazemetostat clinical trial program, patients will receive tazemetostat, an oral first-in-class EZH2 inhibitor, in combination with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) — a standard treatment in newly diagnosed DLBCL.

Epizyme also reported plans to initiate additional clinical evaluations of tazemetostat in 2016, including a combination study with an immune-checkpoint inhibitor in NHL patients, and a monotherapy study in adult mesothelioma patients.

“We are pleased to have established a collaboration with LYSA and to conduct the first investigation of tazemetostat in the front-line treatment setting,” Robert Bazemore, Epizyme’s president and chief executive officer, said in a press release. “This study agreement aligns with Epizyme’s strategy of partnering with world-class research organizations to accelerate our development programs. The planned combination trial builds on preclinical evidence of synergy between tazemetostat and R-CHOP, and will add to what we know about the utility of tazemetostat in patients with non-Hodgkin lymphoma.”

Epizyme and LYSA will lead the Phase 1b/2 clinical trial together with LYSA’s operational arm, the Lymphoma Academic Research Organization (LYSARC), which is sponsoring the study.

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