Revlimid-Rituxan Combo May Replace Chemo, Delay Decline for Some Lymphoma Patients, Phase 3 Trial Shows

Revlimid-Rituxan Combo May Replace Chemo, Delay Decline for Some Lymphoma Patients, Phase 3 Trial Shows

Adding Revlimid (lenalidomide) to Rituxan (rituximab) in the treatment of follicular lymphoma and marginal zone lymphoma patients who failed at least one prior therapy significantly delays disease progression or death, a Phase 3 study shows.

The study, called AUGMENT (NCT01938001), assessed whether Revlimid plus Rituxan would be better than Rituxan alone in patients with indolent (slow-growing) but incurable non-Hodgkin’s lymphomas.

Rituxan, alone or in combination with chemotherapy, is the standard therapy after patients have failed prior treatments. Rituxan is an antibody that targets the CD20 molecule, widely produced by lymphoma cells.

Response rates to Rituxan alone are 40-60%, but rise as high as 90% when it is used along with chemotherapy. However, chemotherapy can produce toxicity that compromises patients’ immune systems, putting them at higher risk of infections. Researchers have been trying to replace chemotherapy with other biologic agents.

Revlimid restores the function of immune cells in the tumors of follicular lymphoma patients. Phase 2 studies have shown response rates ranging from 73-93% in patients treated with a combination of Revlimid and Rituxan.

To study this combination, researchers designed AUGMENT, a controlled trial, which included 358 patients, and randomly assigned them to either Rituxan plus Revlimid, or Rituxan plus a placebo.

Participants had either follicular lymphoma or marginal zone lymphoma and had failed at least one prior treatment with chemotherapy or immunotherapy. They also had received at least two prior doses of Rituxan and demonstrated a response to this therapy.

The study’s primary goal was to determine whether the combination extended a patient’s life without the disease worsening, compared to Rituxan alone. Secondary goals included response rates, overall survival, adverse events, and time to next anti-lymphoma therapy.

The combination showed a trend toward better survival rates in these patients. Its safety profile was consistent with the known profiles of both medications, Revlimid’s maker, Celgene, announced.

“[Slow-growing] non-Hodgkin’s lymphomas, such as follicular lymphoma and marginal zone lymphoma, are diseases of underlying immune dysfunction with a need for new options beyond currently available therapies,” Jay Backstrom, MD, and chief medical officer for Celgene, said in a press release.

“We are encouraged by the highly significant improvement in progression-free survival observed in this study and look forward to engaging with regulatory authorities as soon as possible,” he said. “The R2 regimen represents a potentially new chemotherapy-free option for these patients.”

Data from the study will be submitted to a future medical meeting, while Celgene prepares to submit the combination for approval in the first quarter of 2019.


  1. Diagnosed with MM 4/08. Had failed stem cell transfer, CDT and Velcade and all failed. Now on cycle 32 of the generic lenalidomide and my count is almost undetectable. Main side effects are IBS which at times is bad and facial rash which is unsightly but tolerable. Recently had a blood clot in my arm and had to stop treatment but that is now cleared. Am on 25mg the generic Revlimid and no steroids which is fine as my weight ballooned on steroids.Feel tired at times but hey I’m alive and doing ok.

  2. Emily Jones says:

    The generic brand is manufactured by some company and when you want to buy lenalidomide online, sees the price structure of the medicine by clicking on the brand name. This will show the Lenalidomide cost applicable to the particular type of brand. When developments are made with regard to the medicine, the medicines and generics get updated and new drugs come to the market. The cost for Lenalidomide oral capsule 2.5 mg is around $21,050 for a supply of 28 capsules, depending on the pharmacy you visit. However, when you want to know the Lenalidomide cost in India, you can contact the local vendors as advised by your specialist.

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