Lymphoma News Today

Skip to content
  • Home
  • News Categories
    • Social Clips
    • Hodgkin’s Lymphoma
    • Non-Hodgkin’s Lymphoma
    • Clinical Trial
    • Leukemia & Lymphoma Society
  • About Lymphoma
    • Types Of Lymphoma
      • B-Cell Lymphoma
      • Benign Lymphoma
      • Burkitt’s Lymphoma
      • Cutaneous Lymphoma
      • Follicular Lymphoma
      • Indolent Lymphoma
      • Intestinal Lymphoma
      • Low Grade Lymphoma
      • Mantle Cell Lymphoma
      • Non-Hodgkin’s Lymphoma
    • Lymphoma Symptoms
      • Lymphedema
    • Signs Of Lymphoma
    • Lymphoma Diagnosis
    • Lymphoma Prognosis
  • Treatments
    • Approved Treatments
      • CAR T-cell Therapy
        • Kymriah (Tisagenlecleucel)
        • Yescarta (KTE-C19)
      • Adcetris (Brentuximab Vedotin)
      • Aliqopa (Copanlisib)
      • Arzerra (Ofatumumab)
      • Beleodaq (Belinostat)
      • Bendamustine in Lymphomas
      • Besponsa (Inotuzumab Ozogamicin)
      • Calquence (Acalabrutinib)
      • CPX-351
      • Gazyva (Obinutuzumab)
      • Imbruvica (Ibrutinib)
      • Keytruda for Classical Hodgkin Lymphoma (cHL)
      • Rituxan (Rituximab)
      • Rituxan Hycela
      • Revlimid (lenalidomide)
      • Velcade (bortezomib)
      • Venclexta (Venetoclax)
      • Zydelig (Idelalisib)
    • Experimental Treatments
      • ABP798 for Non-Hodgkin’s Lymphoma
      • ADCT-301 in Lymphomas
      • AFM11 for B-Cell Lymphoma
      • AFM13 for Hodgkin’s Lymphoma
      • ALT-803 for Non-Hodgkin Lymphomas
      • Betalutin
      • CMD-003 for Hodgkin’s and non-Hodgkin’s Lymphomas
      • CX-072
      • CPI-818
      • DI-Leu16-IL2
      • Duvelisib
      • GWN323
      • IGN002 for Non-Hodgkin’s Lymphoma
      • Imfinzi (Durvalumab)
      • JCAR017 for B-Cell Non-Hodgkin’s Lymphoma (NHL)
      • JCAR018
      • KTE-X19
      • Mogamulizumab
      • NM-IL-12
      • Oncoquest-L for Follicular Lymphoma
      • OXS-1550
      • PDR001 in Lymphoma
      • Resimmune
      • RG7741 (GDC-0575)
      • Tecentriq (Atezolizumab)
      • TG-1101 (Ublituximab)
      • TGR-1202 (Umbralisib)
      • Xalkori (Crizotinib)
  • Columns
    • Overcoming Adversity
    • Things That Give Me Hope
    • Life After Lymphoma: A Young Warrior’s Guide to Recovery
  • Information About COVID-19

Personalized Treatment for B cell Lymphoma Patients with Specific ABC Subtype

July 27, 2015July 27, 2015
Patricia Inacio, PhDby Patricia Inacio, PhD

In News.

Personalized Treatment for B cell Lymphoma Patients with Specific ABC Subtype

Click here to subscribe to the Lymphoma News Today Newsletter!

0
(0)

In a new study entitled “Targeting B-Cell Receptor Signaling with Ibrutinib in Diffuse Large B-Cell Lymphoma” a team of researchers identified a subtype of diffuse large B cell lymphoma (DLBCL) – the activated B cell-like (ABC) – that activates a specific enzyme rendering ABC tumor cells more susceptible to ibrutinib treatment. The findings are an example of personalized medicine and will allow clinicians to identify patients more likely to respond to the treatment. The study was published in the journal Nature Medicine.

Lymphomas are a type of blood cancer caused by the abnormal proliferation of a form of white blood cells called lymphocytes. Within the panoply of lymphomas, diffuse large B cell lymphoma (DLBCL) has two major subtypes – activated B cell-like (ABC) and germinal center B cell-like (GCB).

In previous studies, researchers identified the two subtypes based on a different pattern of activated genes, which suggested the potential need for subtype-targeted therapy. Currently, only 40% of ABC patients are cured with the available therapies, which is a significant lower rate when compared to the GCB DLBCL subtype. As such, ABC subtype-specific treatments are required.

In this study, a team of researchers performed a phase II clinical trial in 80 patients suffering from DLBCL who failed to respond to standard treatments or had relapsed. The team treated all patients with ibrutinib, a drug that targets Bruton’s tyrosine kinase (BTK), an enzyme essential for the development and maturation of B lymphocytes.

Complete or partial responses were registered in 37 percent of all ABC DLBCL patients treated with ibrutinib, but this number decrease to only 5 percent in patients with GCB DLBCL. Thus, the new findings show a specific activation of BTK in ABC but not GBC tumors, rendering ABC tumors sensitive to ibrutinib treatment. As a consequence, the team argues that future clinical trials should identify the specific subtype of B cell lymphoma, to correctly identify those patients with an ABC DLBCL signature that will respond to ibrutinib.

Study co-lead author Louis Staudt, M.D., Ph.D., NCI Center for Cancer Genomics, commented, “Clinical trials such as this are critical for translating basic molecular findings into effective therapies.”

Study co-leader Wyndham Wilson, M.D., Ph.D., NCI Center for Cancer Research, added, “This is the first clinical study to demonstrate the importance of precision medicine in lymphomas.”

  • Author Details
Patricia Inacio, PhD
Patricia holds her Ph.D. in Cell Biology from University Nova de Lisboa, and has served as an author on several research projects and fellowships, as well as major grant applications for European Agencies. She also served as a PhD student research assistant in the Laboratory of Doctor David A. Fidock, Department of Microbiology & Immunology, Columbia University, New York.
×
Patricia Inacio, PhD
Patricia holds her Ph.D. in Cell Biology from University Nova de Lisboa, and has served as an author on several research projects and fellowships, as well as major grant applications for European Agencies. She also served as a PhD student research assistant in the Laboratory of Doctor David A. Fidock, Department of Microbiology & Immunology, Columbia University, New York.
Print Friendly, PDF & EmailPrint This Page

How useful was this post?

Click on a star to rate it!

Average rating 0 / 5. Vote count: 0

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?

Tagged B cells, Bruton’s tyrosine kinase (BTK), diffuse large B cell lymphoma (DLBCL), DLBCL activated B cell-like (ABC), DLBCL germinal center B cell-like (GCB), ibrutinib.

Post navigation

Lymphoma PrognosisPrevious: Researchers Discover Link Between Specific Subset of Lymphomas and Metabolism
Next:Algorithm Analysis Of Drug Interactions With Body Chemistry Could Result In More Efficient Drugs With Fewer Side-effects

Recent Posts

  • farewell, honesty, impact, sometimes, superheroes

    A Farewell Note to My Beloved Readers

    February 26, 2021

  • farewell, honesty, impact, sometimes, superheroes

    A Light-giver Shares a Lesson in Emotional Honesty

    February 15, 2021

  • farewell, honesty, impact, sometimes, superheroes

    Embarking on a New Chapter While Cherishing the Value of Community

    February 1, 2021

Featured Posts

FDA Grants Orphan Drug Status to Umbralisib for Follicular Lymphoma

March 19, 2020

Umbralisib orphan drug

The Paradox of Healing

March 9, 2020

grateful, happiness, coronavirus, beauty

Create your own user feedback survey

Visit Lymphoma News Today's profile on Pinterest.

Lymphoma News Today

BioNews Services, LLC
3 W Garden St
Suite 700
Pensacola, FL 32502
Email: [email protected]
Phone: +1-800-936-1363
  • About Us
  • Our Team
  • Our Guiding Ethics
  • Contact Us
  • Terms of Service
  • Privacy Policy
  • Disable Notifications

Disclaimer:

Lymphoma News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
Copyright © 2013-2021 Copyright 2015 © All rights reserved